What to Expect from GLP-1 Medications

Reaching a healthy weight isn't always as simple as eating well and staying active., which is one of the reasons why GLP-1 medications have become an increasingly common way to lose weight. While this can be an effective weight loss method for many people, it’s important to know what to expect when you start on a GLP-1 medication, so you’re not surprised by side effects and understand what lifestyle changes may be needed to set yourself up for success.

What are GLP-1 medications?

Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medication that helps to manage blood sugar levels and promote weight loss. They are also known by the generic names semaglutides, liraglutides, and tirzepatides. There are many GLP-1 options available, so it pays to do a little research on your own first. Your doctor can then help you decide which one will suit your personal health needs.

These medications work by mimicking the GLP-1 hormone that is naturally produced by your small intestine to manage glucose (sugar). This hormone triggers the release of insulin which allows your body to turn the food you eat into energy. It can also regulate blood sugar levels which will slow your digestion and help you to feel fuller faster and longer.   

What to expect when you start GLP-1

When starting your treatment, it’s important to remember that everyone’s experience is unique, and results may vary. Your body will need time to adjust, so your doctor may initially prescribe a low dose that can be increased over time as needed. This gradual introduction can help your body get used to the medication and minimize side effects. 

You may also need to make some lifestyle changes to assist in your weight loss journey. Adjusting your diet and exercise routine in the first month of taking GLP-1 agonists can help minimize side effects and maintain your progress. For example, you may need to: 

• Avoid foods with added sugars to minimize nausea and limit blood sugar spikes that could make it harder for the GLP-1 to work.
• Eat more protein and fiber-rich foods for a balanced diet that aids digestion.
• Start with low-impact activities and limit intensity of your workouts, at first, especially after eating.

What are common side effects of GLP-1?

If you’ve already done some research on GLP-1 medications, you probably know some of the common side effects many people experience in the first few weeks of starting the medication. The most common side effects reported with GLP-1 medications are gastrointestinal issues like nausea and vomiting. With the digestive system being the focus of treatment, you may experience some stomach discomfort and feelings of fullness that may come on quickly as you eat. Side effects can be mild to moderate and can include headaches and dizziness, too. 

The nausea and other side effects tend to be more common at the start and ease as you adjust your habits and get used to the medication. However, if any side effects become severe, be sure to contact your doctor. 

Because many of the GLP-1 medications are taken by injection, you may also notice redness and bruising around the site of injection. This can be minimized by injecting the meds in a different spot each time, but still within the fatty tissue just under your skin. Your doctor will direct you to inject the medication in certain areas, such as the abdomen, upper arm or thigh. You may need to give yourself a shot once a week or each day, depending on the medication and dose prescribed. 

Keep track of your experience

Like any new experience, the amount of change or new information can be daunting at first. To relieve any anxiety or stress, try tracking your daily habits with a journal. Keep records of your meals, side effects, and weight loss to help your doctor monitor your progress and help you stay motivated to reach your goals.